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Select item 101810951.

Functional Landscapes of POLE and POLD1 Mutations in Checkpoint Blockade-Dependent Anti-Tumor Immunity

Xiaoxiao Ma, Nadeem Riaz, Robert M. Samstein, Mark Lee, Vladimir Makarov, Cristina Valero, Diego Chowell, Fengshen Kuo, Douglas Hoen, Conall W.R. Fitzgerald, Hui Jiang, Jonathan Alektiar, Tyler J. Alban, Ivan Juric, Prerana Bangalore Parthasarathy, Yu Zhao, Erich Y. Sabio, Richa Verma, Raghvendra M. Srivastava, Lynda Vuong, Wei Yang, Xiao Zhang, Jingming Wang, Lawrence K. Chu, Stephen L. Wang, Daniel W. Kelly, Xin Pei, Jiapeng Chen, Rona Yaeger, Dmitriy Zamarin, Ahmet Zehir, Mithat Gönen, Luc GT Morris, Timothy A. Chan

Nat Genet. Author manuscript; available in PMC 2023 May 12.

Published in final edited form as: Nat Genet. 2022 Jul; 54(7): 996–1012. Published online 2022 Jul 11. doi: 10.1038/s41588-022-01108-w

PMCID:: PMC10181095

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Select item 106643772.

Rare germline variants in POLE and POLD1 encoding the catalytic subunits of DNA polymerases ε and δ in glioma families

Christine A. M. Weber, Nicole Krönke, Valery Volk, Bernd Auber, Alisa Förster, Detlef Trost, Robert Geffers, Majid Esmaeilzadeh, Michael Lalk, Arya Nabavi, Amir Samii, Joachim K. Krauss, Friedrich Feuerhake, Christian Hartmann, Bettina Wiese, Frank Brand, Ruthild G. Weber

Acta Neuropathol Commun. 2023; 11: 184. Published online 2023 Nov 21. doi: 10.1186/s40478-023-01689-5

PMCID:: PMC10664377

Article PDF–10M

Select item 60329223.

Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response

Daniel Temko, Inge C Van Gool, Emily Rayner, Mark Glaire, Seiko Makino, Matthew Brown, Laura Chegwidden, Claire Palles, Jeroen Depreeuw, Andrew Beggs, Chaido Stathopoulou, John Mason, Ann‐Marie Baker, Marc Williams, Vincenzo Cerundolo, Margarida Rei, Jenny C Taylor, Anna Schuh, Ahmed Ahmed, Frédéric Amant, Diether Lambrechts, Vincent THBM Smit, Tjalling Bosse, Trevor A Graham, David N Church, Ian Tomlinson

J Pathol. 2018 Jul; 245(3): 283–296. Published online 2018 Apr 30. doi: 10.1002/path.5081

PMCID:: PMC6032922

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Select item 97199174.

Distinct clinical pattern of colorectal cancer patients with POLE mutations: A retrospective study on real-world data

Miao Jiang, Yongliang Jia, Jinming Han, Jianxiang Shi, Chang Su, Rui Zhang, Menglu Xing, Shuiling Jin, Hong Zong

Front Genet. 2022; 13: 963964. Published online 2022 Nov 21. doi: 10.3389/fgene.2022.963964

PMCID:: PMC9719917

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Select item 98515615.

C. elegans XMAP215/ZYG-9 and TACC/TAC-1 act at multiple times during oocyte meiotic spindle assembly and promote both spindle pole coalescence and stability

Austin M. Harvey, Chien-Hui Chuang, Eisuke Sumiyoshi, Bruce Bowerman

PLoS Genet. 2023 Jan; 19(1): e1010363. Published online 2023 Jan 6. doi: 10.1371/journal.pgen.1010363

PMCID:: PMC9851561

Article PDF–5.9M

Select item 100702716.

Reconstruction of incomplete X-ray diffraction pole figures of oligocrystalline materials using deep learning

David Meier, Rishan Ragunathan, Sebastian Degener, Alexander Liehr, Malte Vollmer, Thomas Niendorf, Bernhard Sick

Sci Rep. 2023; 13: 5410. Published online 2023 Apr 3. doi: 10.1038/s41598-023-31580-1

PMCID:: PMC10070271

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Select item 84914247.

Distinct mutational profile and immune microenvironment in microsatellite-unstable and POLE-mutated tumors

Hee Sang Hwang, Deokhoon Kim, Jene Choi

J Immunother Cancer. 2021; 9(10): e002797. Published online 2021 Oct 3. doi: 10.1136/jitc-2021-002797

PMCID:: PMC8491424

Article PDF–5.6M

Select item 55497148.

A Pictorial Review of the Many Faces of Gossypiboma – Observations in 6 Cases

Gayatri Pole, Bright Thomas

Pol J Radiol. 2017; 82: 418–421. Published online 2017 Aug 1. doi: 10.12659/PJR.900745

PMCID:: PMC5549714

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Select item 81777579.

POLE mutation spectra are shaped by the mutant allele identity, its abundance and mismatch repair status

Karl P. Hodel, Meijuan J.S. Sun, Nathan Ungerleider, Vivian S. Park, Leonard G. Williams, David L. Bauer, Victoria E. Immethun, Jieqiong Wang, Zucai Suo, Hua Lu, James B. McLachlan, Zachary F. Pursell

Mol Cell. Author manuscript; available in PMC 2021 Jun 18.

Published in final edited form as: Mol Cell. 2020 Jun 18; 78(6): 1166–1177.e6. Published online 2020 Jun 3. doi: 10.1016/j.molcel.2020.05.012

PMCID:: PMC8177757

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Select item 627527310.

Quantitative analysis of sensitivity to a Wnt3a gradient in determination of the pole‐to‐pole axis of mitotic cells by using a microfluidic device

Takumi Hiraiwa, Yuichiro Nakai, Takahiro G. Yamada, Ryuichi Tanimoto, Hiroshi Kimura, Yoshinori Matsumoto, Norihisa Miki, Noriko Hiroi, Akira Funahashi

FEBS Open Bio. 2018 Dec; 8(12): 1920–1935. Published online 2018 Nov 9. doi: 10.1002/2211-5463.12525

PMCID:: PMC6275273

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Select item 697842111.

A biphasic growth model for cell pole elongation in mycobacteria

Mélanie T. M. Hannebelle, Joëlle X. Y. Ven, Chiara Toniolo, Haig A. Eskandarian, Gaëlle Vuaridel-Thurre, John D. McKinney, Georg E. Fantner

Nat Commun. 2020; 11: 452. Published online 2020 Jan 23. doi: 10.1038/s41467-019-14088-z

PMCID:: PMC6978421

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Select item 1089921112.

Male meiotic spindle poles are stabilized by TACC3 and cKAP5/chTOG differently from female meiotic or somatic mitotic spindles in mice

Calvin Simerly, Emily Robertson, Caleb Harrison, Sydney Ward, Charlize George, Jasmine Deleon, Carrie Hartnett, Gerald Schatten

Sci Rep. 2024; 14: 4808. Published online 2024 Feb 27. doi: 10.1038/s41598-024-55376-z

PMCID:: PMC10899211

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Select item 961386913.

Novel POLE mutations identified in patients with IMAGE-I syndrome cause aberrant subcellular localisation and protein degradation in the nucleus

Tomohiro Nakano, Yoji Sasahara, Atsuo Kikuchi, Kunihiko Moriya, Hidetaka Niizuma, Tetsuya Niihori, Matsuyuki Shirota, Ryo Funayama, Keiko Nakayama, Yoko Aoki, Shigeo Kure

J Med Genet. 2022 Nov; 59(11): 1116–1122. Published online 2022 May 9. doi: 10.1136/jmedgenet-2021-108300

PMCID:: PMC9613869

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Select item 528941314.

Mechanical properties of spindle poles are symmetrically balanced

Kazuya Suzuki, Takeshi Itabashi, Shin’ichi Ishiwata

Biophys Physicobiol. 2017; 14: 1–11. Published online 2017 Jan 24. doi: 10.2142/biophysico.14.0_1

PMCID:: PMC5289413

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Select item 936539415.

Three-dimensional structure of kinetochore-fibers in human mitotic spindles

Robert Kiewisz, Gunar Fabig, William Conway, Daniel Baum, Daniel Needleman, Thomas Müller-Reichert

eLife. 2022; 11: e75459. Published online 2022 Jul 27. doi: 10.7554/eLife.75459

PMCID:: PMC9365394

Article PDF–12M

Select item 651979016.

Maternal Nanos inhibits Importin-α2/Pendulin-dependent nuclear import to prevent somatic gene expression in the Drosophila germline

Miho Asaoka, Kazuko Hanyu-Nakamura, Akira Nakamura, Satoru Kobayashi

PLoS Genet. 2019 May; 15(5): e1008090. Published online 2019 May 15. doi: 10.1371/journal.pgen.1008090

PMCID:: PMC6519790

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Select item 599221817.

Molecular profiling and sequential somatic mutation shift in hypermutator tumours harbouring POLE mutations

Keiichi Hatakeyama, Keiichi Ohshima, Takeshi Nagashima, Shumpei Ohnami, Sumiko Ohnami, Masakuni Serizawa, Yuji Shimoda, Koji Maruyama, Yasuto Akiyama, Kenichi Urakami, Masatoshi Kusuhara, Tohru Mochizuki, Ken Yamaguchi

Sci Rep. 2018; 8: 8700. Published online 2018 Jun 7. doi: 10.1038/s41598-018-26967-4

PMCID:: PMC5992218

Article PDF–1.7M

Select item 771107418.

Evidence of Non-microtubule Spindle Forces in Mesostoma ehrenbergii Spermatocytes

Eleni Fegaras-Arch, Michael Berns, Arthur Forer

Front Mol Biosci. 2020; 7: 557990. Published online 2020 Nov 19. doi: 10.3389/fmolb.2020.557990

PMCID:: PMC7711074

Article PDF–6.7M

Select item 1000699719.

The hereditary N363K POLE exonuclease mutant extends PPAP tumor spectrum to glioblastomas by causing DNA damage and aneuploidy in addition to increased mismatch mutagenicity

Guillaume Labrousse, Pierre Vande Perre, Genis Parra, Marion Jaffrelot, Laura Leroy, Frederic Chibon, Frederic Escudie, Janick Selves, Jean-Sebastien Hoffmann, Rosine Guimbaud, Malik Lutzmann

NAR Cancer. 2023 Jun; 5(2): zcad011. Published online 2023 Mar 11. doi: 10.1093/narcan/zcad011

PMCID:: PMC10006997

Article PDF–4.4M

Select item 953168320.

Impact of Plantago ovata Forsk leaf extract on morpho-physio-biochemical attributes, ions uptake and drought resistance of wheat (Triticum aestivum L.) seedlings

Khadiga Alharbi, Haifa Abdulaziz Sakit Alhaithloul, Aisha A. M. Alayafi, Wafa’a A. Al-Taisan, Suliman Mohammed Alghanem, Amina A. M. Al-Mushhin, Mona H. Soliman, Moodi Saham Alsubeie, Dan C. Vodnar, Romina Alina Marc

Front Plant Sci. 2022; 13: 999170. Published online 2022 Sep 20. doi: 10.3389/fpls.2022.999170

PMCID:: PMC9531683

Article PDF–4.7M

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PMC Images search for image pole【机】

Figure 2Comparison of a posterior pole late fluorescein angiogram image from a fundus camera with a posterior pole image from the Optos from the same eye with uveitis

A posterior pole late FA image from a fundus camera (left) is compared with a posterior pole late image from the Optos (right, cropped 200 degree image) in an eye with uveitis. Note that more FA leakage is seen on the Optos image taken in the same sitting as the fundus camera image.

Comparison of Wide-Field Fluorescein Angiography and Nine-Field Montage Angiography in Uveitis

Am J Ophthalmol. ;157(3):673-677.
Figure 1MDCT volume-rendered image showing SRA arising from abdominal aorta - hilar with superior pole and inferior pole extrahilar branches on both sides (anterior view)

SRA: single renal artery, AA: abdominal aorta, H: hilum, CH: common hepatic artery, Sp: splenic artery, RRA: right renal artery, LRA: left renal artery, RSPEx: right superior pole extrahilar branch, LSPEx: left superior pole extrahilar branch, RIPEx: right inferior pole extrahilar branch, LIPEx: left inferior pole extrahilar branch.

Prevalence and Relevance of Multiple Renal Arteries: A Radioanatomical Perspective

Cureus. 2021 Oct;13(10):e18957.
Figure 2

(A) FA/ICG image of the posterior pole of the left eye before verteporfin photodynamic treatment of the feeder vessel complex. Arrow points to the treated spot. (B) FA/ICG image of the posterior pole of the same patient 1 month after verteporfin photodynamic treatment with 100 J/cm² light dose. Arrow shows hypoperfusion of the feeder vessel. (C) FA/ICG image of the posterior pole of the same patient 3 months after verteporfin photodynamic treatment with 100 J/cm² light dose. Arrow shows reperfusion of the feeder vessel. (D) FA image of the posterior pole of the left eye before verteporfin photodynamic treatment of the feeder vessel complex. (E) FA image of the posterior pole of the same patient 1 month after verteporfin photodynamic treatment with 100 J/cm² light dose showing no retinal toxicity at the FV complex treatment site. (F) FA image of the posterior pole of the same patient 3 months after verteporfin photodynamic treatment with 100 J/cm² light dose showing no retinal toxicity at the FV complex treatment site.

Phase I clinical trial results of verteporfin enhanced feeder vessel therapy in subfoveal choroidal neovascularisation in age related macular degeneration

Br J Ophthalmol. 2006 Sep;90(9):1152-1156.
Figure 1

(A) FA/ICG image of the posterior pole of the right eye in a patient before verteporfin photodynamic treatment of the feeder vessel complex. Arrow points to the treated spot. (B) FA/ICG image of the posterior pole of the same patient 1 month after verteporfin photodynamic treatment with 50 J/cm² light dose. Arrow shows closure of the feeder vessel complex. (C) FA/ICG image of the posterior pole of the same patient 3 months after verteporfin photodynamic treatment with 50 J/cm² light dose. Arrow shows reperfusion of the feeder vessel complex. (D) FA image of the posterior pole of the right eye in a patient before verteporfin photodynamic treatment of the feeder vessel complex. (E) FA image of the posterior pole of the same patient 1 month after verteporfin photodynamic treatment with 50 J/cm² light dose showing no retinal toxicity at the FV complex treatment site. (F) FA image of the posterior pole of the same patient 3 months after verteporfin photodynamic treatment with 50 J/cm² light dose showing no retinal toxicity at the FV complex treatment site.

Phase I clinical trial results of verteporfin enhanced feeder vessel therapy in subfoveal choroidal neovascularisation in age related macular degeneration

Br J Ophthalmol. 2006 Sep;90(9):1152-1156.